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Prolonged substance abuse can damage the brain from "summary" of Change Your Brain, Change Your Life: Revised and Expanded Edition by Daniel G. Amen

Prolonged substance abuse can lead to serious damage to the brain. When someone consistently uses drugs or alcohol over an extended period of time, it can have a detrimental effect on the structure and function of their brain. This is because these substances can alter the chemical balance in the brain, affecting important neurotransmitters like dopamine and serotonin. One of the ways in which prolonged substance abuse can damage the brain is by causing changes in the brain's reward system. Drugs and alcohol can trigger the release of large amounts of dopamine, a neurotransmitter associated with pleasure and reward. Over time, the brain may become less responsive to natural rewards, leading the individual to seek out more of the substance to experience the same level of pleasure. Additionally, substance abuse can also impact the brain's ability to regulate emotions and make sound decisions. The prefrontal cortex, the part of the brain responsible for executive functions like decision-making and impulse control, can be negatively affected by long-term substance abuse. This can result in poor judgment, impulsive behavior, and difficulty in controlling emotions. Furthermore, prolonged substance abuse can lead to structural changes in the brain. Chronic drug or alcohol use can cause the deterioration of white matter in the brain, which is crucial for transmitting signals between different regions. This can result in impaired cognitive function, memory problems, and difficulties with learning and attention.
  1. The damaging effects of prolonged substance abuse on the brain are significant and can have long-lasting consequences. It is important for individuals struggling with addiction to seek help and support in order to prevent further harm to their brain and overall well-being.
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Change Your Brain, Change Your Life: Revised and Expanded Edition

Daniel G. Amen

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