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Prolonged substance abuse can damage the brain from "summary" of Change Your Brain, Change Your Life: Revised and Expanded Edition by Daniel G. Amen

Prolonged substance abuse can lead to serious damage to the brain. When someone consistently uses drugs or alcohol over an extended period of time, it can have a detrimental effect on the structure and function of their brain. This is because these substances can alter the chemical balance in the brain, affecting important neurotransmitters like dopamine and serotonin. One of the ways in which prolonged substance abuse can damage the brain is by causing changes in the brain's reward system. Drugs and alcohol can trigger the release of large amounts of dopamine, a neurotransmitter associated with pleasure and reward. Over time, the brain may become less responsive to natural rewards, leading the individual to seek out more of the substance to experience t...
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    Change Your Brain, Change Your Life: Revised and Expanded Edition

    Daniel G. Amen

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