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The brain's reward circuitry can be rewired through abstinence and behavioral changes from "summary" of Never Enough by Judith Grisel

Grisel explains that the brain's reward circuitry, which is responsible for the pleasurable feelings we experience when engaging in certain activities like eating or socializing, can be altered through repeated drug use. These changes can make it difficult for individuals to resist the urge to seek out drugs, even when they know the negative consequences. However, she also points out that this circuitry is not fixed and can be influenced by abstinence and behavioral changes. By abstaining from drug use, individuals give their brains the opportunity to recover and return to a more balanced state. This can help to weaken the connections between drug use and pleasure, making it easier to resist craving...
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    Never Enough

    Judith Grisel

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