DNA damage can contribute to aging from "summary" of Lifespan by David Sinclair,Matthew D. Laplante
DNA damage can lead to a variety of problems, including mutations that can affect the functioning of genes. As we age, our cells accumulate DNA damage from various sources, such as exposure to UV radiation, toxins, and normal cellular processes. This damage can accumulate over time, leading to errors in DNA replication and gene expression. As a result, our cells may not function as efficiently as they once did, leading to a decline in overall health. One of the main consequences of DNA damage is the activation of a cellular defense mechanism called the DNA damage response (DDR). The DDR is a complex network of signaling pathways that are activated in response to D...
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