The brain adapts to chronic drug use by reducing dopamine signaling from "summary" of Never Enough by Judith Grisel
As we continue to use drugs, our brains start to play tricks on us. The very system that once encouraged our drug use now seems to be working against us. Dopamine is the culprit here. We all know that dopamine is the chemical messenger responsible for feelings of pleasure and reward. When we first start using drugs, dopamine floods our system, making us feel euphoric and reinforcing the behavior. But as we keep using drugs, our brains adapt. Chronic drug use causes the brain to reduce dopamine signaling. This means that over time, we need more and more of the drug to feel the same level of pleasure. Our brains become less sensitive to dop...
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