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Withdrawal symptoms can be severe from "summary" of Drugs, Addiction, and the Brain by George F. Koob,Michael A. Arends,Michel Le Moal

When an individual abruptly stops using a drug to which they have become addicted, they may experience a range of physical and psychological symptoms known as withdrawal. These symptoms can be severe and debilitating, often leading individuals to continue using the drug in order to avoid or alleviate them. The severity of withdrawal symptoms can vary depending on the type of drug used, the duration of use, and the individual's unique physiology. Physical symptoms of drug withdrawal can include nausea, vomiting, sweating, tremors, muscle aches, and headaches. These symptoms can be extremely uncomfortable and may last for several days to weeks, depending on the drug. In some cases, withdrawal symptoms can be life-threatening, such as in the case of severe alcohol or opioid withdrawal, which can result in seizures, delirium, and even death if not properly managed. In addition to physical symptoms, individuals going through drug withdrawal may also experience a range of psychological symptoms, including anxiety, depression, irritability, and intense drug cravings. These symptoms can be just as distressing as the physical symptoms and can make it extremely difficult for individuals to abstain from drug use. The severity of drug withdrawal symptoms is a testament to the powerful impact that drugs can have on the brain and body. Chronic drug use can lead to significant changes in the brain's neurochemistry, resulting in physical dependence and tolerance to the drug. When drug use is suddenly stopped, the brain struggles to regain its equilibrium, leading to the manifestation of withdrawal symptoms. It is important for individuals who are struggling with drug addiction to seek professional help when attempting to quit, as medical supervision and support can help to alleviate withdrawal symptoms and prevent relapse. Withdrawal management programs, such as detoxification services, can provide individuals with the necessary medical care and support to safely navigate the withdrawal process and begin their journey to recovery.
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    Drugs, Addiction, and the Brain

    George F. Koob

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