Structureactivity relationships in drug design from "summary" of Chemistry for Pharmacy Students by Lutfun Nahar,Professor Satyajit D. Sarker
Structure-activity relationships (SAR) play a crucial role in the design and development of drugs. This concept involves studying how the chemical structure of a compound affects its biological activity. By understanding the relationship between the structure of a drug molecule and its pharmacological effects, researchers can optimize the design of new drugs with improved efficacy and reduced side effects. In drug design, SAR studies help identify the key structural features of a compound that are responsible for its pharmacological activity. By systematically modifying the chemical structure of a lead compound and evaluating the resulting changes in activity, researchers can pinpoint the functional groups or molecular motifs that are essential for the desired biological effect. This knowledge allows for the rational design of more potent and selective drug...
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