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Structureactivity relationships in drug design from "summary" of Chemistry for Pharmacy Students by Lutfun Nahar,Professor Satyajit D. Sarker

Structure-activity relationships (SAR) play a crucial role in the design and development of drugs. This concept involves studying how the chemical structure of a compound affects its biological activity. By understanding the relationship between the structure of a drug molecule and its pharmacological effects, researchers can optimize the design of new drugs with improved efficacy and reduced side effects. In drug design, SAR studies help identify the key structural features of a compound that are responsible for its pharmacological activity. By systematically modifying the chemical structure of a lead compound and evaluating the resulting changes in activity, researchers can pinpoint the functional groups or molecular motifs that are essential for the desired biological effect. This knowledge allows for the rational design of more potent and selective drugs. One of the main goals of SAR studies is to optimize the pharmacokinetic properties of a drug, such as its absorption, distribution, metabolism, and excretion (ADME). By modifying the structure of a drug molecule, researchers can improve its bioavailability, increase its half-life in the body, or enhance its ability to penetrate biological membranes. These optimizations can lead to more effective and safer drugs for the treatment of various diseases. Moreover, SAR studies can help predict the potential toxicity of a drug candidate. By analyzing the structure-activity relationships of known toxic compounds, researchers can identify structural alerts or pharmacophores that are associated with adverse effects. This information is valuable for avoiding the development of drugs with harmful side effects and improving the safety profiles of new drug candidates.
  1. SAR studies provide valuable insights into the molecular mechanisms underlying the pharmacological activity of drugs. By elucidating the relationship between the chemical structure of a compound and its biological effects, researchers can design more effective and safer drugs for the treatment of various medical conditions.
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Chemistry for Pharmacy Students

Lutfun Nahar

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