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There are distinct pathways in the brain for addition and subtraction from "summary" of The Number Sense by Stanislas Dehaene

Human cognition demonstrates remarkable versatility in processing numerical operations. Addition and subtraction, while closely related, engage different neural pathways. Research indicates that these operations are not merely inverse functions; they activate distinct regions in the brain, suggesting a specialized architecture for arithmetic. When tackling addition, brain imaging studies reveal heightened activity in regions such as the parietal lobes. These areas are implicated in numerical representation and manipulation. This activation highlights the brain’s ability to combine quantities, integrating them into a cohesive total. The process of summing involves visualizing the quantities and the relationships between them, a function deeply rooted in our cognitive structure. Conversely, subtraction engages a different set of neural resources. It often requires a more complex cognitive process, particularly when the operation involves larger numbers or requires borrowing. Neural activity shifts toward regions associated with executive functions, such as the prefrontal cortex. This shift underscores the more strategic nature of subtraction, which demands not only the retrieval of numerical facts but also the manipulation of those facts within a broader cognitive framework. The differentiation in processing suggests that these arithmetic operations are supported by specialized systems. This distinction is further reinforced through developmental studies, where children exhibit varying levels of proficiency in addition and subtraction, often mastering addition before they effectively grasp subtraction. The timing and manner in which children learn these operations reflect their underlying neural architecture, ultimately shaping their numerical understanding. Understanding these pathways enriches the comprehension of mathematical cognition, illustrating how the brain organizes and processes fundamental numerical concepts in distinctly tailored ways.
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    The Number Sense

    Stanislas Dehaene

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