Modulation of glycolysis by hormones from "summary" of The Enzymes of Glycolysis by
Hormones can have a powerful effect on glycolysis, the process of generating energy and storing it in the form of molecules. Through modulation of hormones, glycolysis can be adjusted to meet the body's energy needs, ensuring that it remains in balance.- Hormones serve as important regulators of glycolysis, regulating enzyme activity and transport. For example, hormones such as insulin and glucagon act to modulate glycolysis by inhibiting or stimulating the production of particular enzymes within the glycolytic pathway.
- Also, hormones can impact the cell’s response to hypoxia, helping to adjust the glycolytic pathway to facilitate survival. Adrenaline and glucocorticoids, in particular, play an important role in this process by regulating the expression of several key glycolytic/gluconeogenic genes.
- Hormonal regulation also plays an important role in muscle cell function, specifically concerning contraction. Insulin, epinephrine, and other hormones regulate the activation and inhibition of various enzymes involved in ATP production, thus influencing muscle contraction speed and force.
- Insulin is known to play a regulatory role on glucose transporters, which import and export critical intermediate metabolites across cell membranes. This allows for more efficient disposition of metabolic substrates throughout the body when hormonal signaling is in effect.
