Caloric restriction can slow down the aging process from "summary" of Longevity Diet by Valter Longo
Caloric restriction has been shown to slow down the aging process in various species, including yeast, worms, flies, and mice. Studies have demonstrated that reducing calorie intake by 30-50% can increase the lifespan of these organisms by up to 50%. The benefits of caloric restriction on longevity are believed to be mediated by a variety of mechanisms, including decreased inflammation, improved metabolism, and increased stress resistance. One of the key pathways involved in the anti-aging effects of caloric restriction is the insulin-like growth factor 1 (IGF-1) signaling pathway. When calorie intake is reduced, levels of IGF-1 decrease, which in turn activates a cascade of biochemical reactions that promote cellular repair and regeneration. This ultimately leads to a slowing down of the aging process and a lower risk of age-related diseases. Another important mechanism through which caloric restriction exerts its anti-aging effects is through the activation of sirtuins, a family of proteins that play a critical role in regulating cellular h...
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