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Recognizing bleeding disorders requires a thorough evaluation from "summary" of Hematology Board Review by Francis P. Worden, MD,Rami N. Khoriaty, MD,Kathleen A. Cooney, MD,Michael W. Deininger, MD, PhD

The evaluation of bleeding disorders necessitates a comprehensive approach that encompasses a detailed patient history, physical examination, and laboratory testing. A thorough history should investigate the patient's personal and family history of bleeding symptoms, including the extent, frequency, and duration of bleeding episodes. Additionally, it is crucial to inquire about any potential triggering events, such as trauma, surgery, or medication use. The physical examination plays a vital role in identifying signs of bleeding disorders, including petechiae, ecchymoses, and mucosal bleeding. Furthermore, an assessment of the patient's vital signs, including blood pressure and heart rate, can provide valuable information about the severity of the bleeding disorder. Laboratory testing is essential in confirming a suspected bleeding disorder and determining its underlying cause. Initial tests may include a complete blood count (CBC) with peripheral blood smear, coagulation studies (prothrombin time, activated partial thromboplastin time), and platelet function assays. Depending on the results of these tests, further specialized testing, such as factor assays, von Willebrand factor studies, or genetic testing, may be warranted. In some cases, a bleeding disorder may be secondary to an underlying medical condition, such as liver disease, renal failure, or malignancy. Therefore, a thorough evaluation should also include a review of the patient's medical history and a physical examination to assess for signs of an underlying disorder.
  1. Recognizing bleeding disorders requires a multidisciplinary approach that integrates the patient's history, physical examination, and laboratory testing. Through a systematic and thorough evaluation, healthcare providers can accurately diagnose and manage bleeding disorders, ultimately improving patient outcomes and quality of life.
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Hematology Board Review

Francis P. Worden, MD

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