The brain adapts to drug use over time from "summary" of Drugs, Addiction, and the Brain by George F. Koob,Michael A. Arends,Michel Le Moal
As drug use continues, the brain undergoes adaptations that can fundamentally change its structure and function. These adaptations are a result of the brain's natural ability to adjust to its environment and maintain a state of balance, or homeostasis. When drugs are introduced into the system, they disrupt this delicate balance and trigger a series of compensatory changes in the brain. Over time, these adaptations can lead to tolerance, where higher doses of the drug are needed to achieve the same effects. This occurs because the brain becomes less responsive to the drug's effects and requires larger amounts to produce the desired response. In additi...
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