Solubility and dissolution of drugs from "summary" of Chemistry for Pharmacy Students by Lutfun Nahar,Professor Satyajit D. Sarker
Solubility is a crucial factor that affects the dissolution and ultimately the bioavailability of drugs. When a drug is administered, it needs to dissolve in the body fluids before it can be absorbed into the bloodstream. If a drug is not soluble in the body fluids, it will not be able to dissolve and therefore will not be absorbed effectively. The solubility of a drug is dependent on several factors, including the chemical structure of the drug, the pH of the surrounding environment, and the presence of other substances that may interact with the drug. Drugs that are more hydrophobic tend to have lower solubility in water, while drugs that are more hydrophilic tend to have higher solubility. The dissolution of a drug refers to the p...
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