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Gluten can be detrimental to gut health in some individuals from "summary" of Brain Maker by DAVID. PERLMUTTER

In certain individuals, gluten can wreak havoc on the gut. This protein found in wheat, barley, and rye can set off a cascade of events that leads to inflammation and damage in the intestines. For some people, this damage can then extend beyond the gut and impact other areas of the body, including the brain. The gut is home to trillions of bacteria that play a crucial role in maintaining overall health. When gluten disrupts the delicate balance of these bacteria, it can pave the way for a host of problems. This disruption can lead to a condition known as "leaky gut," where the intestinal barrier becomes compromised and allows harmful substances to leak into the bloodstream. This can trigger an immune response that further fuels inflammation and sets the stage for a range of health issues. Gluten can also trigger the production of zonulin, a protein that regulates the permeability of the intestinal barrier. When zonulin levels are elevated, the tight junctions that hold the intestinal cells together become loose, allowing unwanted particles to pass through. This can lead to systemic inflammation and contribute to a variety of health problems, from digestive issues to neurological disorders. Individuals with certain genetic predispositions, such as those with celiac disease or non-celiac gluten sensitivity, are particularly susceptible to the harmful effects of gluten. For these individuals, even small amounts of gluten can trigger a strong immune response and set off a chain reaction of inflammation and damage in the gut. Given the potential impact of gluten on gut health, it is important for those who suspect they may have a sensitivity to gluten to explore elimination diets and other strategies to identify and address this issue. By taking steps to remove gluten from their diet, individuals can potentially improve their gut health and reduce the risk of associated health problems.
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